Pabna Medical College & Hospital was established in 2008 with a view to fulfilling the basic medical demands of the people of the district and elsewhere. Classes began in 2009 in the temporary cottages of the Pabna Mental Hospital.

In 2015, the modern six-story academic building was inaugurated by Prime Minister Sheikh Hasina. In 2018, construction on separate hostels for both boys and girls began in order to accommodate the increasing number of medical students every year. The preliminary work of creating 500-bed hospital has been completed.